II. Support and Movement 8. Articulations and
Clinical Focus Joint Disorders
Arthritis
Arthritis, an inflammation of any joint, is
the most common and best known of the
jointdisorders, affecting 10% of the world’s
population. More than 100 different types
of arthritis exist. Classification is often
based on the cause and progress of the
arthritis. Causesinclude infectious agents,
metabolic disorders, trauma, and immune
disorders. Mild exercise retardsjointdegen-
eration and enhances mobility. Swimming
and walking are recommended for people
with arthritis; butrunning, tennis, and aero-
bics are not recommended. Therapy de-
pends on the type of arthritis but usually
includesthe use of antiinflammatory drugs.
Currentresearch is focusing on the possible
developmentof antibodies against the cells
that initiate the inflammatory response in
the jointsor against cell surface markers on
those cells.
Osteoarthritis (OA) is the most com-
mon type ofarthritis, affecting 10% of peo-
ple in the United States(85% of those over
age 70). OA maybegin as a molecular ab-
normalityin articular cartilage, with hered-
ity and normal wear-and-tear of the joint
important contributing factors. Slowed
metabolic rates with increased age also
seem to contribute to OA. Inflammation is
usuallysecondary in this disorder. It tends
to occur in the weight-bearing jointssuch as
the knees and is more common in over-
weightindividuals.
The first line of treatment for os-
teoarthritis is to change the lifestyle to re-
duce stress on affected joints. Synovial
jointsrequire movement to remain healthy.
Long periodsof inactivity may cause joints
to stiffen. Moderate exercise helpsreduce
pain and increase flexibility. Exercising also
helps people reduce excessweight, which
can place stress on joints of the lower
limbs. Older people should avoid high-
impactsports, such as jogging, tennis, and
racquetball, which place stress on the
joints. Cycling or walking are recom-
mended, butswimming is the best for peo-
ple with osteoarthritis, as it exercises the
muscles and joints without stressing the
joints. Wearing shock-absorbing shoescan
help. Splints or braces worn over an af-
fected jointmay sometimes be necessary to
properly align the joint and distribute
weightaround it.
Applying heat, such aswith hot soaks,
warm paraffin application, heating pads,
low-power infrared light, or diathermy(mild
electriccurrents that produce heat), directly
over the jointmay be helpful. Moving to a
warmer climate, however, doesn’tseem to
make much difference.
The American GeriatricsSociety has re-
leased guidelines for managing chronic
pain in elderlypatients with osteoarthritis.
They recommend acetaminophen (Tylenol)
or other nonsteroidal antiinflammatory
drugs(NSAIDs), such as aspirin and ibupro-
fen (Advil), for mild to moderate pain. Cap-
saicin, a component of hot red peppers,
may help relieve pain when applied as a
skin cream (Zostrix). Capsaicin seemsto re-
duce levels of a chemical known as
substance P thatcontributesboth to inflam-
mation ofthe joint and to the conduction of
pain sensations to the brain. If pain be-
comes a major problem and over-the-
counter pain relievers appear ineffective,
physicians may inject corticosteroids
directlyinto the affected joint.
Synviscand Hyalgan are two drugs de-
rived from hyaluronic acid, a naturalsub-
stance thatlubricates joints. They may be
administered by injection into the joint
when standard medication and exercise
programsfail to relieve pain. Glucosamine
and chondroitin sulfate are also natural
substancesassociated with joints. If taken
orally or by injection they may help af-
fected joints. However, glucosamine may
also raise blood sugar levels, so people
with diabetesshouldn’t use it without con-
sulting their physician. Injectionsof genet-
ically treated cells from synovial fluid,
which are able to blockthe immune factors
thought to cause the breakdown of joint
cartilage, are currently under investiga-
tion. An immune system protein called
transforming growth factor beta (TGF-),
introduced by gene therapy, is showing
some promise in repairing cartilage dam-
aged byosteoarthritis.
Ifother treatments fail, surgical proce-
duresmay be employed to relieve pain and
increase function in osteoarthritispatients.
Using arthroscopy, a surgeon can examine
the joint and clean outbone and cartilage
fragments that stimulate pain and inflam-
mation. In osteotomy, the bonesof joint are
reshaped to better align the joint. In a pro-
cedure called chondroplasty, a small
amountof healthy cartilage is removed and
grown in the laboratory. The newlygrown
cartilage is then implanted into the joint,
where itmay stimulate the regeneration of
damaged tissue.
Joint replacement isdiscussed at the
end of this Clinical Focus. Ifthe affected
jointcannot be replaced, surgeons mayper-
form a procedure called arthrodesis, in
which the bones meeting at the joint are
fused together. Thisprocedure is intended
to eliminate the pain, butthe joint is elimi-
nated and movementat that point becomes
impossible.
Rheumatoid arthritis (RA) is the sec-
ond most common type of arthritis. It af-
fectsabout 3% of all women and about 1%
ofall men in the United States. It is a gen-
eralconnective tissue disorder that affects
the skin, vessels, lungs, and other organs,
butit is most pronounced in the joints. It is
severelydisabling and most commonly de-
stroys small joints, such as those in the
handsand feet (figure B). The initial cause
isunknown but may involve a transient in-
fection or an autoimmune disease (an im-
mune reaction to one’s own tissues; see
chapter 22) thatdevelops against collagen.
A genetic predisposition may also exist.
Whatever the cause, the ultimate course
appears to be immunologic. People with
classicRA have a protein, rheumatoid fac-
tor, in their blood. In RA the synovial fluid
and associated connective tissue cellspro-
liferate, forming a pannus(clothlike layer),
which causesthe joint capsule to become
thickened and which destroysthe articular
cartilage. In advanced stages, opposing
joint surfaces can become fused. Juvenile
rheumatoid arthritis is similar to the adult
type in manyways, but no rheumatoid fac-
tor isfound in the serum.
Part2 Supportand Movement264